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Diagnosis

_{Not actual patients.}

A PROS diagnosis is the first step to targeted treatment with VIJOICE

PROS is a spectrum of diverse overgrowth disorders caused by a PIK3CA mutation. Understanding the diagnosis of PROS can help you identify which patients may benefit from VIJOICE, the first and only FDA-approved treatment for patients with PROS. A National Institutes of Health (NIH) workshop* proposed the following diagnostic criteria for PROS¹:

NIH Workshop Diagnostic Criteria^*

Congenital or early childhood onset

Sporadic and mosaic overgrowth

2 or more spectrum features OR any 1 isolated feature

Presence of a somatic PIK3CA mutation

A presumptive PROS diagnosis can be considered based on features if a PIK3CA mutation is not identified^1-3

*Clinical diagnostic criteria were determined after a 2-day workshop that included several researchers who have been studying this group of disorders and 3 parent representatives of patient-family support and advocacy organizations for individuals with these conditions. These criteria may change as research develops.¹

Find a multidisciplinary team

The International Society for the Study of Vascular Anomalies (ISSVA) has compiled a list of multidisciplinary teams that treat vascular anomalies, which may be a manifestation of PROS. ISSVA believes "that a team environment is the optimal setting for managing the complex problems that arise in treating vascular anomalies."

To view the list of multidisciplinary care teams, click here ↗