Pediatric Dosing

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Recommended initial dose and dose modifications for pediatric patients (2 to <18 years of age)¹

The recommended initial dosage of VIJOICE in pediatric patients is 50 mg orally, once daily, administered as recommended until disease progression or unacceptable toxicity. Recommended dose adjustments for ARs are available in the Prescribing Information or Patient Management Guide.

Consider a dose increase to 125 mg once daily in pediatric patients ≥ 6 years old for response optimization (clinical/radiological) after 24 weeks of treatment with VIJOICE at 50 mg once daily.^†

Dose reduction back to 50 mg may be required if ARs occur. Discontinue VIJOICE in pediatric patients who cannot tolerate 50 mg daily.

When a pediatric patient turns 18 years old, consider a gradual dose increase up to 250 mg.

Recommended dose adjustment for ARs are available in the Prescribing Information or Patient Management Guide.

Additional information:

• If a dose of VIJOICE is missed, it can be taken with food within 9 hours after the time it is usually taken. After more than 9 hours, skip the dose for that day. The next day, take VIJOICE at the usual time. Instruct patients not to take 2 doses to make up for a missed dose

• If the patient vomits after taking the dose, advise the patient not to take an additional dose on that day and to resume the dosing schedule the next day at the usual time

• If an AR occurs, there are dose reduction and interruption guidelines for VIJOICE. Some patients may need to stop taking the drug