Adult Dosing

_{Not actual patients.}

Recommended dose and dose modifications for adult patients (≥18 years of age)¹

VIJOICE is taken orally, once daily, with food, and at approximately the same time every day until disease progression or unacceptable toxicity occurs.

Dose reductions may be required if an AR occurs.

Discontinue VIJOICE in adults who cannot tolerate 50 mg daily.

Recommended dose adjustment for ARs are available in the Prescribing Information or Patient Management Guide.

Additional information:

• If a dose of VIJOICE is missed, it can be taken with food within 9 hours after the time it is usually taken. After more than 9 hours, skip the dose for that day. The next day, take VIJOICE at the usual time. Instruct patients not to take 2 doses to make up for a missed dose

• If the patient vomits after taking the dose, advise the patient not to take an additional dose on that day and to resume the dosing schedule the next day at the usual time

• If an AR occurs, there are dose reduction and interruption guidelines for VIJOICE. Some patients may need to stop taking the drug