Dosing: Oral Granules

_{Not actual patients.}

VIJOICE oral granules dosage form overview¹

Prescribe the most appropriate dosage form of VIJOICE according to the dose required and patient needs.

VIJOICE oral granules (50 mg per packet):

• For patients who are prescribed a 50 mg daily dose only.

• Do not use multiple 50 mg packets or a partial packet of oral granules for patients prescribed a 125 mg or a 250 mg dose.

• Do not combine VIJOICE tablets and VIJOICE oral granules to achieve the prescribed dose.

Administration overview

Take VIJOICE with food at approximately the same time each day.

If a dose of VIJOICE is missed, it can be taken with food within 9 hours after the time it is usually taken. After more than 9 hours, skip the dose for that day. The next day, take VIJOICE at the usual time.

If the patient vomits after taking the dose, advise the patient not to take an additional dose on that day, and to resume the dosing schedule the next day at the usual time.

VIJOICE oral granules preparation and administration instructions

Administer VIJOICE oral granules directly onto the tongue with water, or prepare as a suspension or a mixture for oral use. To administer via feeding tubes prepare the suspension with water only.

• Each packet is for single use only.

• No packet should be used if the packet seal is broken.

• Do not attempt to use partial quantities of oral granules from 50 mg oral granules packets to prepare a dose. Do not combine VIJOICE tablets and VIJOICE oral granules to achieve the prescribed dose of 125 mg or 250 mg.

• For patients for whom a daily dose of 50 mg is prescribed, administer VIJOICE oral granules in one of the following ways:

• Pour the contents of one VIJOICE oral granules packet directly onto the tongue and swallow with approximately 2 to 4 ounces of water. If needed, rinse the mouth with additional water and swallow to ensure no particles remain in the mouth.

• Pour the contents of one VIJOICE oral granules packet into a cup.

• Add 1 to 3 teaspoons (about 0.5 ounces) of a beverage (water, milk, or apple juice) or soft food (applesauce or yogurt) and stir with a spoon, then administer the suspension or the mixture immediately.

• Rinse the cup with up to 2 ounces of a beverage (water, milk or apple juice) and administer the rinse immediately to ensure the entire dose is administered. If particles remain, repeat until the full dose is administered.

• If not administered immediately after preparation, stir the suspension or the mixture with the same spoon to re-suspend any particles before administration.

• Discard the oral granules mixed with water, milk, apple juice, applesauce, or yogurt if they are not administered within 60 minutes after preparation.

For patients who are not able to swallow VIJOICE orally, administer VIJOICE via feeding tubes.

Administer VIJOICE oral granules via French size 8 to 12 diameter silicone or polyurethane nasogastric tubes or via French size 12 to 24 diameter silicone gastric tubes.

• Pour the contents of one VIJOICE oral granules packet into a cup.

• Add 4 teaspoons (about 0.7 ounces or 20 mL) of water and stir gently with a spoon until a suspension is obtained. Make the suspension with water only.

• Immediately after preparation, withdraw the suspension from the cup into an enteral syringe and administer it via the nasogastric or gastric tube.

• After administration, add 4 teaspoons (about 0.7 ounces or 20 mL) of water to the same cup. Stir with the same spoon to re-suspend any remaining particles. Withdraw the contents of the cup into the same enteral syringe and administer it via the nasogastric or gastric tube. Repeat if particles remain.

• If not administered immediately after preparation, stir the suspension with the same spoon to re-suspend any particles before withdrawing into an enteral syringe for administration.

• Discard the suspension if it is not administered within 60 minutes after preparation.